Drosophila drop-dead mutations accelerate the time course of age-related markers.

  title={Drosophila drop-dead mutations accelerate the time course of age-related markers.},
  author={Blanka Rogina and Seymour Benzer and Stephen L. Helfand},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 12},
Mutations of the drop-dead gene in Drosophila melanogaster lead to striking early death of the adult animal. At different times, after emergence from the pupa, individual flies begin to stagger and, shortly thereafter, die. Anatomical examination reveals gross neuropathological lesions in the brain. The life span of flies mutant for the drop-dead gene is four to five times shorter than for normal adults. That raises the question whether loss of the normal gene product might set into motion a… CONTINUE READING

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