Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.

@article{Whittaker2000DrosophilaDP,
  title={Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.},
  author={Allyson J. Whittaker and Irena Royzman and Terry L Orr-Weaver},
  journal={Genes & development},
  year={2000},
  volume={14 14},
  pages={1765-76}
}
We identified a Drosophila gene, double parked (dup), that is essential for DNA replication and belongs to a new family of replication proteins conserved from Schizosaccharomyces pombe to humans. Strong mutations in dup cause embryonic lethality, preceded by a failure to undergo S phase during the postblastoderm divisions. dup is required also for DNA replication in the adult ovary, establishing that dup is needed for DNA replication at multiple stages of development. Strikingly, DUP protein… CONTINUE READING
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Genet - ics of 51 D52 A , a region containing several maternaleffect genes and two maternalspecific transcripts in Drosophila

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