Drosophila development: A prepattern for sensory organs

  title={Drosophila development: A prepattern for sensory organs},
  author={Pat Simpson},
  journal={Current Biology},
  • P. Simpson
  • Published 1 August 1996
  • Biology
  • Current Biology

Figures from this paper

Regulation of dally, an integral membrane proteoglycan, and its function during adult sensory organ formation of Drosophila.
Dally is established as an important regulator of sensory organ formation via Wg- and Dpp-mediated specification of proneural clusters for dally-sensitive bristles and shows genetic interactions with either wg or dpp signaling components for distinct sensory bristles.
Genetic analysis of bristle loss in hybrids between Drosophila melanogaster and D. simulans provides evidence for divergence of cis-regulatory sequences in the achaete-scute gene complex.
Evidence is provided that bristle loss in the hybrids may result from a decrease in the level of transcription at the achaete-scute complex (AS-C), and it is argued that interaction between trans-acting factors and cis-regulatory elements within the AS-C has diverged between the two species.
Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher Diptera.
At least three genes, scute, lethal of scute and asense have been conserved, thus demonstrating that gene duplication within the achaete-scute complex preceded the separation of the families Drosophilidae and Tephritidae, whose common ancestor goes back more than 100 million years.
Irregular chiasm-C-roughest, a member of the immunoglobulin superfamily, affects sense organ spacing on the Drosophila antenna by influencing the positioning of founder cells on the disc ectoderm
It is proposed that IrreC-rst affects the spatial relationship between sensory and ectodermal cells during FC delamination, which results in an altered arrangement of FCs within the disc compared to wildtype.
Probing the dynamics of cell di erentiation in a model of DrosophilaneurogenesisGeorge
A computational model is formulated of Drosophila early neurogenesis, the process by which neu-roblasts and sensory organ precursor cells differentiate from within proneural clusters of cells, which includes intracellular gene regulatory interactions as well as lateral cell-cell signalling.
Role of dpp signalling in prepattern formation of the dorsocentral mechanosensory organ in Drosophila melanogaster.
The results suggest that Dpp signalling has two indispensable roles in dorsocentrals bristle formation: induction of the dorsocentral proneural cluster in cooperation with Wg signalling and restriction of the wg expression domain in the notum region of the wing imaginal disc.


Patterning of the Drosophila nervous system: the achaete-scute gene complex.
A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila.
A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles.
wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development.
Wingless activity is required at the presumptive wing margin and is a necessary precondition for the change in proliferation pattern in this region, and the time-course of this contribution and the effect on proneural gene expression together suggest that wingless may regulate the activity of products of the achaete-scute complex in proneural clusters.
Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primordia.
The capacity of primordia to respond to sc is temporally and spatially regulated, that specification of the type of SO does not depend on ac/sc, and that SO positioning utilizes topological information independent of the spatially restricted distribution of ac/ sc products are indicated.
pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1.
Molecular analysis of mutant alleles revealed the presence of two functional domains within the pannier protein: a zinc finger domain showing homology to the GATA-1 family of vertebrate transcription factors and a domain comprising two putative amphipathic helices.
The determination of sense organs in Drosophila: a search for interacting genes.
The "gene dose titration" method (Botas et al., 1982) is an efficient method for identifying interacting genes involved in a common process, provided one can identify a well-defined phenotype to look at, and at least one mutation that alters the process.
Cell interactions and gene interactions in peripheral neurogenesis.
This work has revealed that a succession of steps leads from simple anteroposterior heterogeneities in the distribution of a few key factors present in the oocyte to the reproducible establishment of 14 consecutive metameres shortly after cellularization of the embryo.
Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs.
The data indicate that coexpression is accomplished by activation of both ac and sc by the same set of position-specific enhancers, indicating that the enhancers respond to local combinations of factors (prepattern).
Two or three bristles.
  • C. Stern
  • Biology, Medicine
    Science in progress
  • 1955