Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

@article{Hwangbo2004DrosophilaDC,
  title={Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body},
  author={Dae Sung Hwangbo and Boris Gersham and Meng-Ping Tu and Michael Palmer and Marc Tatar},
  journal={Nature},
  year={2004},
  volume={429},
  pages={562-566}
}
In Drosophila melanogaster, ageing is slowed when insulin-like signalling is reduced: life expectancy is extended by more than 50% when the insulin-like receptor (InR) or its receptor substrate (chico) are mutated, or when insulin-producing cells are ablated. But we have yet to resolve when insulin affects ageing, or whether insulin signals regulate ageing directly or indirectly through secondary hormones. Caenorhabditis elegans lifespan is also extended when insulin signalling is inhibited in… Expand
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