Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.

@article{Kiehart2004DrosophilaCM,
  title={Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.},
  author={Daniel P Kiehart and Josef D Franke and Mark K. Chee and Ruth A. Montague and T L Chen and John Roote and Michael Ashburner},
  journal={Genetics},
  year={2004},
  volume={168 3},
  pages={1337-52}
}
Myosin VIIs provide motor function for a wide range of eukaryotic processes. We demonstrate that mutations in crinkled (ck) disrupt the Drosophila myosin VIIA heavy chain. The ck/myoVIIA protein is present at a low level throughout fly development and at the same level in heads, thoraxes, and abdomens. Severe ck alleles, likely to be molecular nulls, die as embryos or larvae, but all allelic combinations tested thus far yield a small fraction of adult "escapers" that are weak and infertile… CONTINUE READING

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