Drosophila-based in vivo assay for the validation of inhibitors of the epidermal growth factor receptor/Ras pathway

@article{Aritakula2008DrosophilabasedIV,
  title={Drosophila-based in vivo assay for the validation of inhibitors of the epidermal growth factor receptor/Ras pathway},
  author={Anuradha Aritakula and Annadurai Ramasamy},
  journal={Journal of Biosciences},
  year={2008},
  volume={33},
  pages={731-742}
}
Overexpression of epidermal growth factor receptor (EGFR) is a common phenomenon observed in most cancers. Clinical treatment of such cancer involves the use of chemotherapeutic agents such as gefitinib and erlotinib which are inhibitors of tyrosine kinase (TK). These small molecules bind to the ATP-binding sites of the TK domain of EGFR. Our in silico analysis suggests that the TK domains of Drosophila and human EGFR are highly conserved. We therefore employed the Drosophila system to validate… CONTINUE READING