Drosophila atonal Fully Rescues the Phenotype of Math1 Null Mice New Functions Evolve in New Cellular Contexts

@article{Wang2002DrosophilaAF,
  title={Drosophila atonal Fully Rescues the Phenotype of Math1 Null Mice New Functions Evolve in New Cellular Contexts},
  author={Vincent Y-C Wang and Bassem A Hassan and Hugo J. Bellen and Huda Y. Zoghbi},
  journal={Current Biology},
  year={2002},
  volume={12},
  pages={1611-1616}
}
Many genes share sequence similarity between species, but their properties often change significantly during evolution. For example, the Drosophila genes engrailed and orthodenticle and the onychophoran gene Ultrabithorax only partially substitute for their mouse or Drosophila homologs. We have been analyzing the relationship between atonal (ato) in the fruit fly and its mouse homolog, Math1. In flies, ato acts as a proneural gene that governs the development of chordotonal organs (CHOs), which… CONTINUE READING

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