Drosophila as a model for context-dependent tumorigenesis.

  title={Drosophila as a model for context-dependent tumorigenesis.},
  author={Marla Tipping and Norbert Perrimon},
  journal={Journal of cellular physiology},
  volume={229 1},
Drosophila can exhibit classic hallmarks of cancer, such as evasion of apoptosis, sustained proliferation, metastasis, prolonged survival, genome instability, and metabolic reprogramming, when cancer-related genes are perturbed. In the last two decades, studies in flies have identified several tumor suppressor and oncogenes. However, the greatest strength of the fly lies in its ability to model cancer hallmarks in a variety of tissue types, which enables the study of context-dependent… CONTINUE READING
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