Drosophila VAP-33A Directs Bouton Formation at Neuromuscular Junctions in a Dosage-Dependent Manner

  title={Drosophila VAP-33A Directs Bouton Formation at Neuromuscular Junctions in a Dosage-Dependent Manner},
  author={Giuseppa Pennetta and Peter Robin Hiesinger and Ruth Fabian-Fine and Ian A. Meinertzhagen and Hugo J. Bellen},
Aplysia VAP-33 (VAMP-associated protein) has been previously proposed to be involved in the control of neurotransmitter release. Here, we show that a Drosophila homolog of VAP-33, DVAP-33A, is localized to neuromuscular junctions. Loss of DVAP-33A causes a severe decrease in the number of boutons and a corresponding increase in bouton size. Conversely, presynaptic overexpression of DVAP-33A induces an increase in the number of boutons and a decrease in their size. Gain-of-function experiments… CONTINUE READING
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and partial characterization of a plant VAP33 homologue with a Synaptic development is controlled in the periactive zones of Dro

  • M. 3723–3732. Sone, E. Suzuki, +6 authors P. de Wit
  • 2000
Highly Influential
7 Excerpts

Insulin-like receptor myces cerevisiae

  • M. Gorczyca, C. Augart, V. Budnik
  • J. Biochem. (Tokyo)
  • 1993
Highly Influential
4 Excerpts

Regulation of Bouton Budding by DVAP-33A

  • J. Schultz, J. M. Rick, A. M. Michon, Cruciat, C.M
  • 2002

and kinesin are interdependent and essential for fast axonal transport

  • J. Schultz, A. M. Michon, C. M. Cruciat
  • Mol . Biol . Cell
  • 2002

A sperm cytoskeletal protein L.S

  • M. A. Miller, V. Q. Nguyen, +9 authors D. Greenstein
  • Drosophila. J. Cell Biol
  • 2001
1 Excerpt

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