Drosophila VAP-33A Directs Bouton Formation at Neuromuscular Junctions in a Dosage-Dependent Manner

@article{Pennetta2002DrosophilaVD,
  title={Drosophila VAP-33A Directs Bouton Formation at Neuromuscular Junctions in a Dosage-Dependent Manner},
  author={Giuseppa Pennetta and Peter Robin Hiesinger and Ruth Fabian-Fine and Ian A. Meinertzhagen and Hugo J. Bellen},
  journal={Neuron},
  year={2002},
  volume={35},
  pages={291-306}
}
Aplysia VAP-33 (VAMP-associated protein) has been previously proposed to be involved in the control of neurotransmitter release. Here, we show that a Drosophila homolog of VAP-33, DVAP-33A, is localized to neuromuscular junctions. Loss of DVAP-33A causes a severe decrease in the number of boutons and a corresponding increase in bouton size. Conversely, presynaptic overexpression of DVAP-33A induces an increase in the number of boutons and a decrease in their size. Gain-of-function experiments… CONTINUE READING
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