Drosophila Unc-13 is essential for synaptic transmission

  title={Drosophila Unc-13 is essential for synaptic transmission},
  author={Bharathi Aravamudan and Tim Fergestad and Warren S. Davis and Chris K. Rodesch and Kendal Broadie},
  journal={Nature Neuroscience},
The UNC-13 protein family has been suggested to be critical for synaptic vesicle dynamics based on its interactions with Syntaxin, Munc-18 and Doc 2α. We cloned the Drosophila homolog (Dunc-13) and characterized its function using a combination of electrophysiology and ultrastructural analyses. Dunc-13 contained a C1 lipid-binding motif and two C2 calcium-binding domains, and its expression was restricted to neurons. Elimination of dunc-13 expression abolished synaptic transmission, an effect… CONTINUE READING
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