Drosophila Ten-m and Filamin Affect Motor Neuron Growth Cone Guidance

  title={Drosophila Ten-m and Filamin Affect Motor Neuron Growth Cone Guidance},
  author={Lihua Zheng and Yehudit Michelson and Vita Freger and Ziva Avraham and Koen J. T. Venken and Hugo J. Bellen and Monica J Justice and Ron Wides},
  booktitle={PloS one},
The Drosophila Ten-m (also called Tenascin-major, or odd Oz (odz)) gene has been associated with a pair-rule phenotype. We identified and characterized new alleles of Drosophila Ten-m to establish that this gene is not responsible for segmentation defects but rather causes defects in motor neuron axon routing. In Ten-m mutants the inter-segmental nerve (ISN) often crosses segment boundaries and fasciculates with the ISN in the adjacent segment. Ten-m is expressed in the central nervous system… CONTINUE READING
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