Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis

@article{Pedraza2004DrosophilaSK,
  title={Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis},
  author={Laura G. Pedraza and Rodney A Stewart and Da-ming Li and Tian Xu},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={4754-4762}
}
Elevated Src protein levels and activity are associated with the development and progression of a variety of cancers. The consequences of deregulated Src activity have been studied extensively in cell culture; however, the effects of this deregulation in vivo, as well as the mechanisms of Src-induced tumorigenesis, remain poorly understood. In this study, the effect of expressing wild-type and constitutively active Drosophila Src-family kinases (SFKs) in the developing eye was examined… CONTINUE READING