Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.

@article{Huang2011DrosophilaSN,
  title={Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.},
  author={Hai Huang and Guiping Du and Hanqing Chen and Xuehong Liang and Changqing Li and Nannan Zhu and Lei Xue and Jun Ma and Renjie Jiao},
  journal={Development},
  year={2011},
  volume={138 12},
  pages={2477-85}
}
Post-translational modification by the small ubiquitin-related modifier (SUMO) is important for a variety of cellular and developmental processes. However, the precise mechanism(s) that connects sumoylation to specific developmental signaling pathways remains relatively less clear. Here, we show that Smt3 knockdown in Drosophila wing discs causes phenotypes resembling JNK gain of function, including ectopic apoptosis and apoptosis-induced compensatory growth. Smt3 depletion leads to an… CONTINUE READING

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