Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner

@article{Kolesnikova2012DrosophilaSP,
  title={Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner},
  author={Tatyana D Kolesnikova and Olga V. Posukh and Eugeniya N. Andreyeva and Darya S. Bebyakina and Anton V. Ivankin and Igor F. Zhimulev},
  journal={Chromosoma},
  year={2012},
  volume={122},
  pages={55-66}
}
Drosophila SUUR (Suppressor of UnderReplication) protein was shown to regulate the DNA replication elongation process in endocycling cells. This protein is also known to be the component of silent chromatin in polyploid and diploid cells. To mark the different cell cycle stages, we used immunostaining patterns of PCNA, the main structural component of replication fork. We demonstrate that SUUR chromatin binding is dynamic throughout the endocyle in Drosophila salivary glands. We observed that… CONTINUE READING
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