Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability

@article{Shi2008DrosophilaSI,
  title={Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability},
  author={Song Shi and Kimberly R Larson and Dongdong Guo and Su Jun Lim and Pranabananda Dutta and Shian-Jang Yan and Willis X. Li},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={489-496}
}
STAT (Signal transducer and activator of transcription) is a potent transcription factor and its aberrant activation by phosphorylation is associated with human cancers. We have shown previously that overactivation of JAK, which phosphorylates STAT, disrupts heterochromatin formation globally in Drosophila melanogaster. However, it remains unclear how this effect is mediated and whether STAT is involved. Here, we demonstrate that Drosophila STAT (STAT92E) is involved in controlling… CONTINUE READING
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