Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division.

@article{David2005DrosophilaRR,
  title={Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division.},
  author={Nicolas B David and Charlotte A. Martin and Marion S{\'e}galen and François Rosenfeld and François Schweisguth and Yohanns Bella{\"i}che},
  journal={Nature cell biology},
  year={2005},
  volume={7 11},
  pages={1083-90}
}
Localization and activation of heterotrimeric G proteins have a crucial role during asymmetric cell division. The asymmetric division of the Drosophila sensory precursor cell (pl) is polarized along the antero-posterior axis by Frizzled signalling and, during this division, activation of Galphai depends on Partner of Inscuteable (Pins). We establish here that Ric-8, which belongs to a family of guanine nucleotide-exchange factors for Galphai, regulates cortical localization of the subunits… CONTINUE READING