Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells

@article{HanyuNakamura2008DrosophilaPP,
  title={Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells},
  author={Kazuko Hanyu-Nakamura and Hiroko Sonobe-Nojima and Akie Tanigawa and Paul Lasko and Akira Nakamura},
  journal={Nature},
  year={2008},
  volume={451},
  pages={730-733}
}
Germ cells are the only cells that transmit genetic information to the next generation, and they therefore must be prevented from differentiating inappropriately into somatic cells. A common mechanism by which germline progenitors are protected from differentiation-inducing signals is a transient and global repression of RNA polymerase II (RNAPII)-dependent transcription. In both Drosophila and Caenorhabditis elegans embryos, the repression of messenger RNA transcription during germ cell… CONTINUE READING
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