Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.

@article{MacAlpine2010DrosophilaOL,
  title={Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.},
  author={Heather K. MacAlpine and Raluca Gord{\^a}n and Sara Powell and Alexander J. Hartemink and David M. MacAlpine},
  journal={Genome research},
  year={2010},
  volume={20 2},
  pages={201-11}
}
The origin recognition complex (ORC) is an essential DNA replication initiation factor conserved in all eukaryotes. In Saccharomyces cerevisiae, ORC binds to specific DNA elements; however, in higher eukaryotes, ORC exhibits little sequence specificity in vitro or in vivo. We investigated the genome-wide distribution of ORC in Drosophila and found that ORC localizes to specific chromosomal locations in the absence of any discernible simple motif. Although no clear sequence motif emerged, we… CONTINUE READING
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