Drosophila Neuroblast Asymmetric Cell Division: Recent Advances and Implications for Stem Cell Biology

  title={Drosophila Neuroblast Asymmetric Cell Division: Recent Advances and Implications for Stem Cell Biology},
  author={Fengwei Yu and Chay T. Kuo and Yuh Nung Jan},
Asymmetric cell division is an evolutionarily conserved mechanism widely used to generate cellular diversity during development. Drosophila neuroblasts have been a useful model system for studying the molecular mechanisms of asymmetric cell division. In this minireview, we focus on recent progress in understanding the role of heterotrimeric G proteins and their regulators in asymmetric spindle geometry, as well as the role of an Inscuteable-independent microtubule pathway in asymmetric… CONTINUE READING

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