Drosophila Nedd4 Regulates Endocytosis of Notch and Suppresses Its Ligand-Independent Activation

  title={Drosophila Nedd4 Regulates Endocytosis of Notch and Suppresses Its Ligand-Independent Activation},
  author={Tadashi Sakata and Hiromi Sakaguchi and Leo Tsuda and Atsushi Higashitani and Toshiro Aigaki and Kenji Matsuno and Shigeo Hayashi},
  journal={Current Biology},
BACKGROUND Ligand-induced proteolytic cleavage and internalization of the plasma membrane receptor Notch leads to its activation. Ligand-independent, steady-state internalization of Notch, however, does not lead to activation. The mechanism by which downstream effectors discriminate between these bipartite modes of Notch internalization is not understood. Nedd4 is a HECT domain-containing E3 ubiquitin ligase that targets transmembrane receptors containing the PPSY motif for endocytosis. Deltex… CONTINUE READING
Highly Cited
This paper has 105 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 67 extracted citations

Targeting the ubiquitin pathway for cancer treatment.

Biochimica et biophysica acta • 2015
View 5 Excerpts
Highly Influenced

Drosophila Ndfip is a novel regulator of Notch signaling

Cell Death and Differentiation • 2011
View 6 Excerpts
Highly Influenced

106 Citations

Citations per Year
Semantic Scholar estimates that this publication has 106 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 19 references

Down - regulation of detection and rapid molecular identification of genes in Dro - Notch target gene expression by Suppressor of deltex . Dev . sophila melanogaster

G. Toba, T. Ohsako, +10 authors M. Baron
Genetics • 2003

Mechanisms underlying ubiquitination.

Annual review of biochemistry • 2001

Multiple roles for Rsp 5 p - depen - and dominant negative forms of the receptor

R. Dunn, L. Hicke
Cell • 2001