Drosophila Nedd4 Regulates Endocytosis of Notch and Suppresses Its Ligand-Independent Activation

@article{Sakata2004DrosophilaNR,
  title={Drosophila Nedd4 Regulates Endocytosis of Notch and Suppresses Its Ligand-Independent Activation},
  author={Tadashi Sakata and Hiromi Sakaguchi and Leo Tsuda and Atsushi Higashitani and Toshiro Aigaki and Kenji Matsuno and Shigeo Hayashi},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={2228-2236}
}

• Tadashi Sakata, Hiromi Sakaguchi, +4 authors Shigeo Hayashi
• Published 2004 in Current Biology
• DOI:10.1016/j.cub.2004.12.028

BACKGROUND Ligand-induced proteolytic cleavage and internalization of the plasma membrane receptor Notch leads to its activation. Ligand-independent, steady-state internalization of Notch, however, does not lead to activation. The mechanism by which downstream effectors discriminate between these bipartite modes of Notch internalization is not understood. Nedd4 is a HECT domain-containing E3 ubiquitin ligase that targets transmembrane receptors containing the PPSY motif for endocytosis. Deltex… CONTINUE READING

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