Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity

  title={Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity},
  author={R. Grace Zhai and Yu Cao and P. Robin Hiesinger and Yi Zhou and Sunil Q. Mehta and Karen L Schulze and Patrik Verstreken and Hugo J. Bellen},
  journal={PLoS Biology},
  pages={423 - 429}
Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wld(s)) mice overexpress a chimeric protein containing the NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase 1) and exhibit a delay in axonal degeneration. Currently, conflicting evidence raises questions as to whether NMNAT is the protecting factor and whether its enzymatic activity is required for such a possible function. Importantly, the link between nmnat… CONTINUE READING
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