Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis.

@article{Jin2005DrosophilaMI,
  title={Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis.},
  author={Zhigang Jin and Ellen M. Homola and Philip Goldbach and Yunhee Choi and Julie A Brill and Shelagh D. Campbell},
  journal={Development},
  year={2005},
  volume={132 18},
  pages={4075-85}
}
The metazoan Wee1-like kinases Wee1 and Myt1 regulate the essential mitotic regulator Cdk1 by inhibitory phosphorylation. This regulatory mechanism, which prevents Cdk1 from triggering premature mitotic events, is also induced during the DNA damage response and used to coordinate cell proliferation with crucial developmental events. Despite the previously demonstrated role for Myt1 regulation of Cdk1 during meiosis, relatively little is known of how Myt1 functions at other developmental stages… CONTINUE READING

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