Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.

@article{SchreiberAgus1997DrosophilaMI,
  title={Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.},
  author={Nicole Schreiber-Agus and David Stein and Kuey-chu Chen and Jason S Goltz and Leslie Stevens and Ronald A. Depinho},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 4},
  pages={1235-40}
}
Biochemical and biological activities of Myc oncoproteins are highly dependent upon their association with another basic region helix-loop-helix/leucine zipper (bHLH/LZ) protein, Max. Our previous observation that the DNA-binding/dimerization region of Max is absolutely conserved throughout vertebrate evolution provided the basis for a yeast two-hybrid interaction screen that led to the isolation of the Drosophila Myc (dMyc1) protein. Structural conservation in regions of known functional… CONTINUE READING

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