Drosophila Myc Regulates Organ Size by Inducing Cell Competition

@article{Cova2004DrosophilaMR,
  title={Drosophila Myc Regulates Organ Size by Inducing Cell Competition},
  author={C. Cova and Mauricio Abril and P. Bellosta and P. Gallant and L. Johnston},
  journal={Cell},
  year={2004},
  volume={117},
  pages={107-116}
}
Experiments in both vertebrates and invertebrates have illustrated the competitive nature of growth and led to the idea that competition is a mechanism of regulating organ and tissue size. We have assessed competitive interactions between cells in a developing organ and examined their effect on its final size. We show that local expression of the Drosophila growth regulator dMyc, a homolog of the c-myc protooncogene, induces cell competition and leads to the death of nearby wild-type cells in… Expand
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