Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

  title={Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections},
  author={S. Tauszig-Delamasure and H. Bilak and M. Capovilla and J. Hoffmann and J. Imler},
  journal={Nature Immunology},
  • S. Tauszig-Delamasure, H. Bilak, +2 authors J. Imler
  • Published 2002
  • Biology, Medicine
  • Nature Immunology
  • We report here the identification and functional characterization of DmMyD88, a gene encoding the Drosophila homolog of mammalian MyD88. DmMyD88 combines a Toll–IL-1R homology (TIR) domain and a death domain. Overexpression of DmMyD88 was sufficient to induce expression of the antifungal peptide Drosomycin, and induction of Drosomycin was markedly reduced in DmMyD88-mutant flies. DmMyD88 interacted with Toll through its TIR domain and required the death domain proteins Tube and Pelle to… CONTINUE READING
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