Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

@article{TauszigDelamasure2002DrosophilaMI,
  title={Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections},
  author={Servane Tauszig-Delamasure and Hana Bilak and Maria Capovilla and Jules A. Hoffmann and Jean-Luc Imler},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={91-97}
}
We report here the identification and functional characterization of DmMyD88, a gene encoding the Drosophila homolog of mammalian MyD88. DmMyD88 combines a Toll–IL-1R homology (TIR) domain and a death domain. Overexpression of DmMyD88 was sufficient to induce expression of the antifungal peptide Drosomycin, and induction of Drosomycin was markedly reduced in DmMyD88-mutant flies. DmMyD88 interacted with Toll through its TIR domain and required the death domain proteins Tube and Pelle to… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 56 references

Drosophila MyD88 is an adapter in the Toll signaling pathway.

Proceedings of the National Academy of Sciences of the United States of America • 2001

How the immune system works to protect the host from infection: a personal view.

Proceedings of the National Academy of Sciences of the United States of America • 2001

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses

S Vidal
Genes Dev 15, • 2001

Toll - like receptors control activation of adaptive immune responses

M. Schnare
Nature Immunol . • 2001

two paths to NF-κB

R. S. Khush, F. Leulier, Lemaitre, B. Drosophila immunity
Trends Immunol. 22, 260–264 • 2001