Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

@article{Shin2011DrosophilaMM,
  title={Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling},
  author={Seung Chul Shin and Sung-Hee Kim and Hyejin You and Boram Kim and Aeri C. Kim and Kyung-Ah Lee and Joo-Heon Yoon and Ji-Hwan Ryu and Won-Jae Lee},
  journal={Science},
  year={2011},
  volume={334},
  pages={670 - 674}
}
Successful development of fruit flies depends on a gut bacterium that interacts with its host’s insulin-signaling pathway. The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone–dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in… 
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Recent studies using the Drosophila model that directly link microbiota-derived metabolites and ISC function are reviewed, providing exciting perspectives for putative future treatments of ISC-related diseases based on monitoring and manipulating intestinal microbiota.
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