Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

@article{Shin2011DrosophilaMM,
  title={Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling},
  author={Seung Chul Shin and Sung-Hee Kim and Hyejin You and Boram Kim and Aeri C. Kim and Kyung-Ah Lee and Joo-Heon Yoon and Ji-Hwan Ryu and Won-Jae Lee},
  journal={Science},
  year={2011},
  volume={334},
  pages={670 - 674}
}
Successful development of fruit flies depends on a gut bacterium that interacts with its host’s insulin-signaling pathway. The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone–dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in… 
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It is found that Arc1 exhibits tissue-specific microbiota-dependent expression changes, and that flies bearing a null mutation of Arc1 complete larval development at a dramatically slowed rate compared to wild-type animals, revealing a novel role for Arc1 in modulating insulin signaling, metabolic homeostasis, and growth rate that is specific to the host’s microbial and nutritional environment.
Metabolic cooperation among commensal bacteria supports Drosophila juvenile growth under nutritional stress
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Using Drosophila as a host model, it is reported that two of its major bacterial partners, Lactobacillus plantarum and Acetobacter pomorum engage in a beneficial metabolic dialogue that boosts host juvenile growth despite nutritional stress.
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