Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters.

@article{Park2001DrosophilaMC,
  title={Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters.},
  author={Jin Mo Park and Byung Soo Gim and Jung Mo Kim and Jin Ho Yoon and Hyun Soo Kim and Jeong Gu Kang and Yu Jung Kim},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 7},
  pages={2312-23}
}
To decipher the mechanistic roles of Mediator proteins in regulating developmental specific gene expression and compare them to those of TATA-binding protein (TBP)-associated factors (TAFs), we isolated and analyzed a multiprotein complex containing Drosophila Mediator (dMediator) homologs. dMediator interacts with several sequence-specific transcription factors and basal transcription machinery and is critical for activated transcription in response to diverse transcriptional activators. The… CONTINUE READING

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