Drosophila Mcm10 Is Required for DNA Replication and Differentiation in the Compound Eye

@inproceedings{Vo2014DrosophilaMI,
  title={Drosophila Mcm10 Is Required for DNA Replication and Differentiation in the Compound Eye},
  author={Nicole Vo and Ayano Taga and Yasuhiro Inaba and Hideki Yokohama-shi Yoshida and Sue Cotterill and Masamitsu Yamaguchi},
  booktitle={PloS one},
  year={2014}
}
Mini chromosome maintenance 10 (Mcm10) is an essential protein, which is conserved from S. cerevisiae to Drosophila and human, and is required for the initiation of DNA replication. Knockdown of Drosophila Mcm10 (dMcm10) by RNA interference in eye imaginal discs induces abnormal eye morphology (rough eye phenotype), and the number of ommatidia is decreased in adult eyes. We also observed a delay in the S phase and M phase in eye discs of dMcm10 knockdown fly lines. These results show important… CONTINUE READING
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