Drosophila I-R hybrid dysgenesis is associated with catastrophic meiosis and abnormal zygote formation.

@article{Orsi2010DrosophilaIH,
  title={Drosophila I-R hybrid dysgenesis is associated with catastrophic meiosis and abnormal zygote formation.},
  author={Guillermo A. Orsi and Eric F Joyce and Pierre Couble and Kim S McKim and Benjamin Loppin},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 20},
  pages={3515-24}
}
The Drosophila I-R type of hybrid dysgenesis is a sterility syndrome (SF sterility) associated with the mobilization of the I retrotransposon in female germ cells. SF sterility results from a maternal-effect embryonic lethality whose origin has remained unclear since its discovery about 40 years ago. Here, we show that meiotic divisions in SF oocytes are catastrophic and systematically fail to produce a functional female pronucleus at fertilization. As a consequence, most embryos from SF… CONTINUE READING