Drosophila Hsc70-4 Is Critical for Neurotransmitter Exocytosis In Vivo

  title={Drosophila Hsc70-4 Is Critical for Neurotransmitter Exocytosis In Vivo},
  author={Peter Bronk and Julia J. Wenniger and Ken Dawson-Scully and Xiufang Guo and Susie Hong and Harold L. Atwood and Konrad E. Zinsmaier},
Previous in vitro studies of cysteine-string protein (CSP) imply a potential role for the clathrin-uncoating ATPase Hsc70 in exocytosis. We show that hypomorphic mutations in Drosophila Hsc70-4 (Hsc4) impair nerve-evoked neurotransmitter release, but not synaptic vesicle recycling in vivo. The loss of release can be restored by increasing external or internal Ca(2+) and is caused by a reduced Ca(2+) sensitivity of exocytosis downstream of Ca(2+) entry. Hsc4 and CSP are likely to act in common… CONTINUE READING

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