Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

@article{Lu2013DrosophilaHR,
  title={Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.},
  author={Xingwu Lu and Sandeep N. Wontakal and Harsh Kavi and Byung Ju Kim and Paloma M. Guzzardo and Alexander V. Emelyanov and Na Xu and Gregory J Hannon and Jiri Zavadil and Dmitry V Fyodorov and Arthur I. Skoultchi},
  journal={Science},
  year={2013},
  volume={340 6128},
  pages={
          78-81
        }
}
Eukaryotic genomes harbor transposable elements and other repetitive sequences that must be silenced. Small RNA interference pathways play a major role in their repression. Here, we reveal another mechanism for silencing these sequences in Drosophila. Depleting the linker histone H1 in vivo leads to strong activation of these elements. H1-mediated silencing occurs in combination with the heterochromatin-specific histone H3 lysine 9 methyltransferase Su(var)3-9. H1 physically interacts with Su… CONTINUE READING
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