Drosophila Futsch/22C10 Is a MAP1B-like Protein Required for Dendritic and Axonal Development

  title={Drosophila Futsch/22C10 Is a MAP1B-like Protein Required for Dendritic and Axonal Development},
  author={Thomas Hummel and Karin Krukkert and Jack Roos and Graeme W Davis and Christian Kl{\"a}mbt},
Here we report the description of the Drosophila gene futsch, which encodes a protein recognized by the monoclonal antibody 22C10 that has been widely used to visualize neuronal morphology and axonal projections. The Futsch protein is 5327 amino acids in length. It localizes to the microtubule compartment of the cell and associates with microtubules in vitro. The N- and C-terminal domains of Futsch are homologous to the vertebrate MAP1B microtubule-associated protein. The central domain of the… CONTINUE READING
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