Drosophila Filamin encoded by the cheerio locus is a component of ovarian ring canals

@article{Sokol1999DrosophilaFE,
  title={Drosophila Filamin encoded by the cheerio locus is a component of ovarian ring canals},
  author={Nicholas Samuel Sokol and Lynn Cooley},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={1221-1230}
}
BACKGROUND The ring canals in the ovary of the fruit fly Drosophila provide a versatile system in which to study the assembly and regulation of membrane-associated actin structures. Derived from arrested cleavage furrows, ring canals allow direct communication between cells. The robust inner rim of filamentous actin that attaches to the ring-canal plasma membrane contains cytoskeletal proteins encoded by the hu-li-tao shao (hts) and kelch genes, and is regulated by the Src64 and Tec29 tyrosine… CONTINUE READING

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The small GTPase RalA targets filamin to induce filopodia.

Proceedings of the National Academy of Sciences of the United States of America • 1999
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