Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.

@article{Kuo2014DrosophilaFH,
  title={Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.},
  author={H. Kenny Kuo and Susan McMahan and Christopher M Rota and Kathryn P. Kohl and Jeff Sekelsky},
  journal={Genetics},
  year={2014},
  volume={198 3},
  pages={935-45}
}
Several helicases function during repair of double-strand breaks and handling of blocked or stalled replication forks to promote pathways that prevent formation of crossovers. Among these are the Bloom syndrome helicase BLM and the Fanconi anemia group M (FANCM) helicase. To better understand functions of these helicases, we compared phenotypes of Drosophila melanogaster Blm and Fancm mutants. As previously reported for BLM, FANCM has roles in responding to several types of DNA damage in… CONTINUE READING
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FANCM limits meiotic crossovers.

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