Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers.

  title={Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers.},
  author={Sarah J. Radford and Elizabeth M Goley and Kimberly R Baxter and Susan McMahan and Jeff Sekelsky},
  volume={170 4},
Drosophila MEI-9 is the catalytic subunit of a DNA structure-specific endonuclease required for nucleotide excision repair (NER). The enzymatic activity of this endonuclease during NER requires the presence of a second, noncatalytic subunit called ERCC1. In addition to its role in NER, MEI-9 is required for the generation of most meiotic crossovers. To better understand the role of MEI-9 in crossover formation, we report here the characterization of the Drosophila Ercc1 gene. We created an… CONTINUE READING


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