Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases.

@article{Yogev2008DrosophilaES,
  title={Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases.},
  author={Shaul Yogev and Eyal D Schejter and Ben-Zion Shilo},
  journal={The EMBO journal},
  year={2008},
  volume={27 8},
  pages={
          1219-30
        }
}
We explore the role of differential compartmentalization of Rhomboid (Rho) proteases that process the Drosophila EGF receptor ligands, in modulating the amount of secreted ligand and consequently the level of EGF receptor (EGFR) activation. The mSpitz ligand precursor is retained in the ER, and is trafficked by the chaperone Star to a late compartment of the secretory pathway, where Rho-1 resides. This work demonstrates that two other Rho proteins, Rho-2 and Rho-3, which are expressed in the… CONTINUE READING

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