Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

@article{Letsou1995DrosophilaDS,
  title={Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family},
  author={Anthea Letsou and Kavita Arora and Jeffrey L. Wrana and Karl Simin and Vern Twombly and Joumana Jamal and Karen Staehling-Hampton and F.Michael Hoffmann and William M. Gelbart and Joan Massagu{\'e} and Michael B O'connor},
  journal={Cell},
  year={1995},
  volume={80},
  pages={899-908}
}
Signaling by TGF beta-related factors requires ligand-induced association between type I and type II transmembrane serine/threonine kinases. In Drosophila, the saxophone (sax) and thick veins (tkv) genes encode type I receptors that mediate signaling by decapentaplegic (dpp), a member of the bone morphogenetic protein (BMP) subgroup of TGF beta-type factors. In this report, we demonstrate that the Drosophila punt gene encodes atr-II, a previously described type II receptor that on its own is… CONTINUE READING