Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B.

@article{Jacobs1998DrosophilaCB,
  title={Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B.},
  author={Henning W. Jacobs and Juergen A. Knoblich and Christian F Lehner},
  journal={Genes & development},
  year={1998},
  volume={12 23},
  pages={3741-51}
}
Cyclin B3 has been conserved during higher eukaryote evolution as evidenced by its identification in chicken, nematodes, and insects. We demonstrate that Cyclin B3 is present in addition to Cyclins A and B in mitotically proliferating cells and not detectable in endoreduplicating tissues of Drosophila embryos. Cyclin B3 is coimmunoprecipitated with Cdk1(Cdc2) but not with Cdk2(Cdc2c). It is degraded abruptly during mitosis like Cyclins A and B. In contrast to these latter cyclins, which… CONTINUE READING

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