Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression

@inproceedings{Gosnell2011DrosophilaCI,
  title={Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression},
  author={Justin A. Gosnell and Tim W. Christensen},
  booktitle={BMC Molecular Biology},
  year={2011}
}
BackgroundProper coordination of the functions at the DNA replication fork is vital to the normal functioning of a cell. Specifically the precise coordination of helicase and polymerase activity is crucial for efficient passage though S phase. The Ctf4 protein has been shown to be a central member of the replication fork and links the replicative MCM helicase and DNA polymerase α primase. In addition, it has been implicated as a member of a complex that promotes replication fork stability, the… CONTINUE READING
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