Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis.

@article{Xu2001DrosophilaCI,
  title={Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis.},
  author={Jinbo Xu and Shengchang Xin and Wei Du},
  journal={FEBS letters},
  year={2001},
  volume={508 3},
  pages={394-8}
}
Chk2 is a major target of ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR). Germline mutations in Chk2 have been identified in a subset of patients with Li-Fraumeni syndrome, suggesting that Chk2 is a tumor suppressor gene. To investigate the role of Chk2 in multicellular organisms, a Drosophila chk2 (Dmchk2) mutant was generated. Dmchk2 mutants are viable but show defects in maintaining genome stability and are highly sensitive to ionizing radiation. Interestingly, mutating… CONTINUE READING