Drosophila CENH3 is sufficient for centromere formation.

  title={Drosophila CENH3 is sufficient for centromere formation.},
  author={Mar{\'i}a Jos{\'e} Mendiburo and Jan Padeken and Stefanie F{\"u}l{\"o}p and Aloys Schepers and Patrick Heun},
  volume={334 6056},
CENH3 is a centromere-specific histone H3 variant essential for kinetochore assembly. Despite its central role in centromere function, there has been no conclusive evidence supporting CENH3 as sufficient to determine centromere identity. To address this question, we artificially targeted Drosophila CENH3 (CENP-A/CID) as a CID-GFP-LacI fusion protein to stably integrated lac operator (lacO) arrays. This ectopic CID focus assembles a functional kinetochore and directs incorporation of CID… CONTINUE READING
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