Drosophila CBP is required for dorsal–dependent twist gene expression

  title={Drosophila CBP is required for dorsal–dependent twist gene expression},
  author={Hiroshi Akimaru and D C Hou and Shunsuke Ishii},
  journal={Nature Genetics},
Although CREB-binding protein (CBP) functions as a co-activator of many transcription factors1–3, relatively little is known about the physiological role of CBP. Mutations in the human CBP gene are associated with Rubinstein-Taybi syndrome, a haplo-insufficiency disorder characterized by abnormal pattern formation4. Recently, we isolated a Drosophila CBP (dCBP) mutant5, and found dCBP to be maternally expressed, suggesting that it plays a role in early embryogenesis. Mesoderm formation is one… CONTINUE READING

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