Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression.

@article{Phippen2000DrosophilaCB,
  title={Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression.},
  author={Taryn M. Phippen and Andrea L. Sweigart and Mariko Moniwa and Anton A Krumm and James R. Davie and Susan M Parkhurst},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 48},
  pages={37628-37}
}
Drosophila C-terminal binding protein (dCtBP) and Groucho have been identified as Hairy-interacting proteins required for embryonic segmentation and Hairy-mediated transcriptional repression. While both dCtBP and Groucho are required for proper Hairy function, their properties are very different. As would be expected for a co-repressor, reduced Groucho activity enhances the hairy mutant phenotype. In contrast, reduced dCtBP activity suppresses it. We show here that dCtBP can function as either… CONTINUE READING
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