Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.

@article{Mukherjee2016DrosophilaBA,
  title={Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.},
  author={Subhas Mukherjee and Carol Tucker-Burden and Changming Zhang and Kenneth H. Moberg and Renee D Read and Constantinos G Hadjipanayis and Daniel J. Brat},
  journal={Cancer research},
  year={2016},
  volume={76 8},
  pages={2443-52}
}
Cancer stem cells exert enormous influence on neoplastic behavior, in part by governing asymmetric cell division and the balance between self-renewal and multipotent differentiation. Growth is favored by deregulated stem cell division, which enhances the self-renewing population and diminishes the differentiation program. Mutation of a single gene in Drosophila, Brain Tumor (Brat), leads to disrupted asymmetric cell division resulting in dramatic neoplastic proliferation of neuroblasts and… CONTINUE READING
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Notch1 signaling is mediated by importins alpha 3, 4, and 7

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