Drosophila Brain Tumor is a translational repressor.

  title={Drosophila Brain Tumor is a translational repressor.},
  author={Junichiro Sonoda and Robin Wharton},
  journal={Genes & development},
  volume={15 6},
The Drosophila brain tumor (brat) gene encodes a member of the conserved NHL family of proteins, which appear to regulate differentiation and growth in a variety of organisms. One of the founding family members, Caenorhabditis elegans LIN-41, is thought to control posttranscriptional gene expression. However, the mechanism by which LIN-41, or any other NHL protein, acts has not been clear. Using a yeast "four-hybrid" interaction assay, we show that Brain Tumor is recruited to hunchback (hb… CONTINUE READING
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