Drosophila Big bang regulates the apical cytocortex and wing growth through junctional tension

@inproceedings{Tsoumpekos2018DrosophilaBB,
  title={Drosophila Big bang regulates the apical cytocortex and wing growth through junctional tension},
  author={Giorgos Tsoumpekos and Linda Nemetschke and Elisabeth Knust},
  booktitle={The Journal of cell biology},
  year={2018}
}
Growth of epithelial tissues is regulated by a plethora of components, including signaling and scaffolding proteins, but also by junctional tension, mediated by the actomyosin cytoskeleton. However, how these players are spatially organized and functionally coordinated is not well understood. Here, we identify the Drosophila melanogaster scaffolding protein Big bang as a novel regulator of growth in epithelial cells of the wing disc by ensuring proper junctional tension. Loss of big bang… CONTINUE READING
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