Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development.

@article{Sevrioukov2007DrosophilaBP,
  title={Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development.},
  author={Evgueni A Sevrioukov and John Burr and Eric W Huang and Hikmat H Assi and Jessica P. Monserrate and Dianne C Purves and Julie N. Wu and Eyun J Song and Carrie Baker Brachmann},
  journal={Genesis},
  year={2007},
  volume={45 4},
  pages={184-93}
}
Many developing tissues require programmed cell death (PCD) for proper formation. In mice and C. elegans, developmental PCD is regulated by the Bcl-2 family of proteins. Two bcl-2 genes are encoded in the Drosophila genome (debcl/dBorg1/Drob-1/dBok and buffy/dBorg2) and previous RNAi-based studies suggested a requirement for these in embryonic development. However, we report here that, despite the fact that many tissues in fruit flies are shaped by PCD, deletion of the bcl-2 genes does not… CONTINUE READING

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