Drosophila ASPP regulates C-terminal Src kinase activity.

  title={Drosophila ASPP regulates C-terminal Src kinase activity.},
  author={Paul Francis Langton and Julien Colombani and Birgit L. Aerne and Nicolas Tapon},
  journal={Developmental cell},
  volume={13 6},
Src-family kinases (SFKs) control a variety of biological processes, from cell proliferation and differentiation to cytoskeletal rearrangements. Abnormal activation of SFKs has been implicated in a wide variety of cancers and is associated with metastatic behavior (Yeatman, 2004). SFKs are maintained in an inactive state by inhibitory phosphorylation of their C-terminal region by C-terminal Src kinase (Csk). We have identified Drosophila Ankyrin-repeat, SH3-domain, and Proline-rich-region… CONTINUE READING