Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function.

@article{Schmitz2000DrosophilaAI,
  title={Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function.},
  author={S. Schmitz and J. Clayton and Upendra Nongthomba and Heino Prinz and Claudia Veigel and Michael A. Geeves and John C. Sparrow},
  journal={Journal of molecular biology},
  year={2000},
  volume={295 5},
  pages={1201-10}
}
Many eukaryotic proteins are co and post-translationally modified at their N termini by removal of one or two amino acid residues and N(alpha)-acetylation. Actins show two different forms of N-terminal processing dependent on their N-terminal sequence. In class II actins, which include muscle actins, the common primary sequence of Met-Cys-Asp-actin is processed to acetyl-Asp-actin. The functional significance of this in vivo is unknown. We have studied the indirect flight muscle-specific actin… CONTINUE READING
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