Drosophila: the genetics of innate immune recognition and response.

@article{Brennan2004DrosophilaTG,
  title={Drosophila: the genetics of innate immune recognition and response.},
  author={Catherine A. Brennan and Kathryn V Anderson},
  journal={Annual review of immunology},
  year={2004},
  volume={22},
  pages={457-83}
}
Because of the evolutionary conservation of innate mechanisms of host defense, Drosophila has emerged as an ideal animal in which to study the genetic control of immune recognition and responses. The discovery that the Toll pathway is required for defense against fungal infection in Drosophila was pivotal in studies of both mammalian and Drosophila immunity. Subsequent genetic screens in Drosophila to isolate additional mutants unable to induce humoral responses to infection have identified and… CONTINUE READING
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